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KMID : 0358819880150020193
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1988 Volume.15 No. 2 p.193 ~ p.200
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EFFECTS OF CYCLOSPORIN
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곽승일/Kwak, Sung Il
이덕주/위성신/임풍/Lee, Duk Joo/Wee, Sung Shin/Lim, Poong
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Abstract
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The repair of large peripheral nerve defects after injury is one of the most vexing problems in the reconstructive surgery of the extremities. The best means of repairing a nerve defect is autologous nerve graft, however, in many cases an autograft cannot be used because the length of the lesion and the diameter of the nerve involved are so great that the patient cannot spare a suitable graft without considerable neurological loss and the most logical solution to it would be nerve allografts if they could be made to work (Young´),
1942: Marmor2>3), 1963, 1964).
Many nerve allografts have been attempted clinically and experimentally with results of various degrees and the main cause of failure was rejection response (Medawar4), 1944; Das Guptas), 1967; Ducker & Hayes6), 1970).
Cyclosporin-A is a new immunosuppressive agent that is effective in preventing the rejection of allografts in animals and man (White et a1.7), 1979; Morris$), 1981).
The aim of this study is to assess the effect of cyclosporin-A on prevention of the rejection of nerve allografts in the rat and, furthermore, the authors attempted to know the fate of the allografts after administration of cyclosporin-A during only the regeneration period of the grafted nerve.
25 mm-segments of the right sciatic nerve of 27 donor rats were transplanted to the right sciatic nerve of 27 recipient rats. These recipients were divided into three groups; Control group: no treatment.
Group A: treated with cyclosporin-A for 12 weeks(l5m/kg/day for 2 weeks, 15mg/kg/ every 4 days after 2 weeks).
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